While his designs often carry a raw, natural quality reflective of his sculptural roots, his contemporary paintings of African women showcase a completely different style. His acrylic works on canvas are whimsical and full-bodied, often described as Picasso-like in their structure.
Setordji has participated in numerous solo and group exhibitions in Ghana and internationally, including in the USA, Great Britain, Holland, Germany, Belgium, and several African countries. Notably, he collaborated with Nat Nunoo-Amarteifio in an exhibition at Nubuke Foundation titled Architectural Heritage of Accra (21st–28th June 2009), aimed at documenting images of historic buildings in Accra before their demolition to make way for new structures.
In 1990, Setordji was named "Artist of the Year." Among his major works are two large bas-reliefs: one at the Kotoka International Airport in Accra and the other at the Kwame Nkrumah Mausoleum.
A founding member of Workshop 358 Artists Collective, based in Accra, Kofi Setordji continues to push creative boundaries in sculpture, painting, and beyond, leaving an indelible mark on Ghana’s artistic heritage.